Dear canEvolve users; CanEvolve supports different type of analysis. Please choose your analysis below and configure your settings. You can access more detail about analysis from "Tutorial" tab. If you need more information or help please send us an e-mail. (help [at] canevolve {dot} org) Thank you. CanEvolve Team Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute To cite your use of the canEvolve project, please reference
canEvolve: A Web Portal for Integrative Oncogenomics
Cancer Type:
Show All
Multiple Myeloma (47)
Lung Cancer (1)
Brain Cancer (2)
Breast Cancer (6)
Colorectal Cancer (3)
Liver Cancer (1)
Oesophageal Cancer (1)
Thyroid Cancer (1)
Kidney Cancer (2)
Prostate Cancer (2)
Pancreatic Cancer (1)
Ovarian Cancer (1)
Your Gene List:
MSigDB defined pathways
An Example:
Click "Get Studies" button and select a dataset from right list (i.e. Results ID:5 GSE2113)
Copy and paste the following gene symbols to the gene list input area and then click "Get Results"
IL4
PTPRC
IL7
CEBPG
SLA2
TNFSF13
NFAM1
INHA
TPD52
TGFB1
HDAC5
HDAC4
INHBA
LAT2
CD40LG
LAX1
CD79A
HDAC9
NHEJ1
Cancer Type:
Show All
Multiple Myeloma (15)
Liver Cancer (1)
Prostate Cancer (1)
Kidney Cancer (1)
Germ Cell Tumor (1)
Your miRNA List:
An Example:
Click "Get Studies" button and select a dataset from right list (i.e. Results ID:1 GSE16558)
Copy and paste the following miRNA symbols to the gene list input area and then click "Get Results"
HSA-MIR-99A
HSA-MIR-99B
HSA-MIR-98
HSA-MIR-96
HSA-MIR-95
Cancer Type:
Show All
Multiple Myeloma (3)
Lung Cancer (3)
Brain Cancer (4)
Breast Cancer (5)
Colorectal Cancer (2)
Liver Cancer (1)
Oesophageal Cancer (2)
Leukemia (3)
Kidney Cancer (1)
Prostate Cancer (3)
Lymphoma (5)
Your Gene List:
An Example:
Click "Get Studies" button and select a dataset from right list (i.e. Results ID:26 GSE9845)
Copy and paste the following gene symbols to the gene list input area and then click "Get Results"
TP53
E2F2
Cancer Type:
Show All
Bladder Cancer (1)
Lung Cancer (2)
Breast Cancer (1)
Cervical Cancer (1)
Colorectal Cancer (2)
Brain Cancer (1)
Kidney Cancer (1)
Leukemia (1)
Prostate Cancer (1)
Stomach Cancer (1)
Thyroid Cancer (1)
Endometrial Cancer (1)
Gene Symbol:
If you want to use another gene symbol for gene expression data please specify it!
Example 1:
Click "Get Studies" button and select a dataset from right list (i.e. ID:2 LUAD)
Copy and paste the following gene symbol to the gene symbol input area and then click "Get Results"
TP53
Example 2:
Click "Get Studies" button and select a dataset from right list (i.e. ID:2 LUAD)
Copy and paste "TP53" to the gene symbol input area and put "MYC" to the second input then click "Get Results"
Cancer Type:
Show All
Lung Cancer (1)
Breast Cancer (1)
Colorectal Cancer (2)
Brain Cancer (1)
Kidney Cancer (1)
Thyroid Cancer (1)
Endometrial Cancer (1)
Gene Symbol:
Select Protein Symbol:
14-3-3_epsilon-M-C
4E-BP1_pS65-R-V
4E-BP1_pT170-R-V
4E-BP1_pT37-R-V
4E-BP1_pT70-R-C
4E-BP1-R-V
53BP1-R-C
A-Raf_pS299-R-NA
ACC_pS79-R-V
ACC1-R-C
AIB1-M-V
Akt_pS473-R-V
Akt_pT308-R-V
Akt-R-V
alpha-Catenin-M-V
AMPK_alpha-R-C
AMPK_pT172-R-V
ANLN-M-NA
Annexin_I-R-V
AR-R-V
ARID1A-M-V
ASNS-R-C
ATM-R-C
ATM-R-NA
B-Raf-M-NA
Bad_pS112-R-V
Bak-R-C
Bax-R-V
Bcl-2-M-V
Bcl-2-R-C
Bcl-2-R-NA
Bcl-X-R-C
Bcl-xL-R-C
Bcl-xL-R-V
Beclin-G-V
beta-Catenin-R-V
Bid-R-C
Bim-R-V
c-Jun_pS73-R-C
c-Kit-R-V
c-Met_pY1235-R-C
c-Met-M-C
c-Myc-R-C
C-Raf_pS338-R-C
C-Raf-R-V
Caspase-3_active-R-C
Caspase-7_cleavedD198-R-C
Caspase-8-M-C
Caspase-9_cleavedD330-R-C
Caveolin-1-R-V
CD20-R-C
CD31-M-V
CD49b-M-V
CDK1-R-V
Chk1_pS345-R-C
Chk1-R-C
Chk1-R-V
Chk2_pT68-R-C
Chk2-M-C
cIAP-R-V
Claudin-7-R-V
Collagen_VI-R-V
COX-2-R-C
Cyclin_B1-R-V
Cyclin_D1-R-V
Cyclin_E1-M-V
Cyclin_E2-R-C
DJ-1-R-C
Dvl3-R-V
E-Cadherin-R-V
eEF2-R-V
eEF2K-R-V
EGFR_pY1068-R-V
EGFR_pY1173-R-C
EGFR_pY992-R-V
EGFR-R-C
eIF4E-R-V
ER-alpha_pS118-R-V
ER-alpha-R-V
ERCC1-M-C
ERK2-R-C
ERK2-R-NA
FAK-R-C
Fibronectin-R-C
FOXO3a_pS318_S321-R-C
FOXO3a-R-C
GAB2-R-V
GATA3-M-V
GSK3_pS9-R-V
GSK3-alpha-beta_pS21_S9-R-V
GSK3-alpha-beta-M-V
HER2_pY1248-R-NA
HER2_pY1248-R-V
HER2-M-V
HER3_pY1298-R-C
HER3_pY1298-R-V
HER3-M-C
HER3-R-V
HSP70-R-C
IGF-1R-beta-R-C
IGFBP2-R-V
INPP4B-G-C
IRS1-R-V
JNK_pT183_pT185-R-V
JNK_pT183_Y185-R-V
JNK2-R-C
K-Ras-M-C
Ku80-R-C
LBK1-M-NA
Lck-R-V
LKB1-M-C
LKB1-M-NA
MAPK_pT202_Y204-R-V
MEK1_pS217_S221-R-V
MEK1-R-V
MIG-6-M-V
Mre11-R-C
MSH2-M-C
MSH6-R-C
mTOR_pS2448-R-C
mTOR-R-V
N-Cadherin-R-V
NEK7-R-NA
NF-kB-p65_pS536-R-C
NF2-R-C
Notch1-R-V
Notch3-R-C
P-Cadherin-R-C
P-REX1-R-NA
p21-R-C
p27_pT157-R-C
p27_pT198-R-V
p27-R-V
p38_MAPK-R-C
p38_pT180_Y182-R-V
p53-R-V
p70S6K_pT389-R-V
p70S6K-R-V
p90RSK_pT359_S363-R-C
Pal-1-M-C
PARP_cleaved-M-C
Paxillin-R-V
PCNA-M-V
PDK1_pS241-R-V
Pea-15-R-V
PEA-15-R-V
PI3K-p110-alpha-R-C
PI3K-p85-R-V
PKC-alpha_pS657-R-V
PKC-alpha-M-V
PKC-delta_pS664-R-V
PR-R-V
PRAS40_pT246-R-V
PRDX1-R-NA
PTCH-R-C
PTEN-R-V
Rab11-R-V
Rab25-R-C
Rad50-M-C
Rad51-M-C
Rb_pS807_S811-R-V
Rb-M-V
RBM3-M-NA
S6_pS235_S236-R-V
S6_pS240_S244-R-V
S6-R-C
S6-R-NA
SETD2-R-C
SETD2-R-NA
Shc_pY317-R-C
Shc_pY317-R-NA
Smac-M-V
Smad1-R-V
Smad3-R-V
Smad4-M-C
Smad4-M-V
Snail-M-C
Src_pY416-R-C
Src_pY527-R-V
Src-M-V
STAT3_pY705-R-V
STAT5-alpha-R-V
Stathmin-R-V
Syk-M-V
Tau-M-C
TAZ_pS89-R-C
TAZ-R-C
TFF1-R-V
TIGAR-R-V
Transglutaminase-M-V
Tuberin-R-C
VASP-R-C
VEGFR2-R-C
VEGFR2-R-V
XBP1-G-C
XIAP-R-C
XRCC1-R-C
YAP_pS127-R-C
YAP-R-V
YB-1_pS102-R-V
YB-1-R-V
Example:
Click "Get Studies" button and select a dataset from right list (i.e. ID:5 LUAD)
Add "TP53" to the gene symbol input and select or write "ACC1-R-C" to the protein symbol input then click "Get Results"
Cancer Type:
Show All
Multiple Myeloma (8)
Breast Cancer (1)
Colorectal Cancer (1)
Kidney Cancer (1)
Prostate Cancer (1)
Pancreatic Cancer (1)
Your Gene Symbol:
An Example:
Click "Get Studies" button and select a dataset from right list (i.e. Results ID:1 GSE6477)
Write "SP1" to the gene symbol area and then click "Show Aracne Network"
Cancer Type:
Show All
Multiple Myeloma (8)
Breast Cancer (2)
Kidney Cancer (1)
Prostate Cancer (2)
Pancreatic Cancer (1)
Colorectal Cancer (1)
Brain Cancer (1)
An Example:
Click "Get Studies" button and select a dataset from right list (i.e. Results ID:1 GSE6477)
Click "Show WGCNA Results"
Cancer Type:
Show All
Multiple Myeloma (1)
Lung Cancer (6)
Lymphoma (2)
Brain Cancer (1)
Breast Cancer (5)
Colorectal Cancer (4)
Leukemia (3)
Your Gene Symbol:
MSigDB defined pathways
An Example:
Click "Get Studies" button and select a dataset from right list (i.e. Results ID:1 GSE2658)
Write "C21ORF45" to the gene symbol area and then click "Show Survival Results"
Note: In KM plot red curve indicates the samples that gene expression levels higher than median and blue curve indicates the samples that gene expression levels lower than median!
Cancer Type:
Show All
Multiple Myeloma (5)
Brain Cancer (2)
Breast Cancer (4)
Colorectal Cancer (2)
Kidney Cancer (2)
Prostate Cancer (2)
Pancreatic Cancer (1)
Ovarian Cancer (1)
An Example:
Click "Get Studies" button and select a dataset from right list (i.e. GSEA ID:12 GSE6477)
Click "Show GSEA Results"
Cancer Type:
Show All
Lung Cancer (2)
Liver Cancer (1)
Kidney Cancer (1)
Prostate Cancer(1)
Germ Cell Tumor (1)
An Example:
Click "Get Studies" button and select a dataset from right list (i.e. Results ID:1 GSE16441)
Click "Show GemiNi Results"
Cancer Type:
Show All
Multiple Myeloma (2)
Breast Cancer (1)
Liver Cancer (1)
Prostate Cancer (1)
Ovarian Cancer (1)
Genes you are interested:
An Example:
Click "Get Studies" button and select a dataset from right list (i.e. DRI ID:2 GSE23720)
Copy and paste the following gene symbols to the gene list input area and then click "Get Results"
WHSC1L1
CLNS1A
ERBB2
GRB7
Your Gene Symbol:
An Example:
Write "TP53" to the gene symbol area and then click "Show Protein-Protein Interaction" button
Please select multiple dataset and pathway to start analysis.
Please select your analysis type and then use the "Get Studies" function! If you need more help, you can check the "Tutorial" tab!
MSigDB defined pathways
Select studies for comparision
MSigDB defined pathways
Select studies for comparision